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While PrEP has not been found to have any serious side effects, two major studies showed that high tenofovir levels were associated with a slight decline in kidney function (measured by glomerular filtration rate). On average, a 2.5% decrease in kidney function was observed over 18 months.
A good emergency supply kit should include: A first-aid kit with bandages, medications, antiseptic wipes, etc. An NOAA weather radio for weather...
Read More »A person becomes infected with HIV when it evades the body’s natural defences and replicates. While there are numerous ways a person can be exposed to HIV, the most common routes of infection involve sexual contact and shared injection equipment. Pre-Exposure Prophylaxis, or PrEP, is an HIV prevention method for people who are not infected with HIV but are at a high risk of contraction. Packaged in a pill called Truvada, PrEP is a cocktail of two drugs (tenofovir and emtricitabine) that are usually used to treat HIV positive patients. By blocking the action of viral reverse transcriptase, PrEP prevents the transcription of viral DNA and can reduce the viral load in the patient. Using the same mechanism, PrEP can also be used to prevent HIV from establishing itself in a healthy individual. In a review of multiple PrEP clinical trials, PrEP was found to be highly effective in preventing HIV infection if patients took the pill consistently. PrEP reduced the risk of infection through sexual contact and injection drugs by approximately 90% and 74%, respectively. PrEP is only recommended for individuals who are continuously under high risk of contracting HIV. While PrEP has not been found to have any serious side effects, two major studies showed that high tenofovir levels were associated with a slight decline in kidney function (measured by glomerular filtration rate). On average, a 2.5% decrease in kidney function was observed over 18 months. However, older populations were more heavily affected. Decreases in kidney function ranged from 6-24% in participants over the age of 50. While the decreases in kidney function are mild, people who have predisposed risk factors should monitor their kidney function while taking PrEP. While PrEP seems to be a safe and effective HIV prevention method, long term studies should be done on the risks and side effects of PrEP. Since PrEP is prescribed to healthy individuals, even minor toxicities could be a concern.
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Read More »If your partner is newly diagnosed with HIV and has only just started treatment, you may want to consider PrEP until their viral load becomes undetectable. If you have sex without a condom with more than one sexual partner and don't know their status, HIV PrEP can reduce your chance of becoming infected with HIV.
A serodiscordant partnership is where one partner is HIV negative and the other is living with HIV. If you're HIV negative and your sexual partner is living with HIV, you might want to consider PrEP in certain circumstances. If your partner has been diagnosed with HIV, has been taking HIV medication for at least 6 months, and their viral load is undetectable, there is no risk of HIV transmission through sex. An undetectable viral load means that the level of HIV in their body is too low to be measured by a blood test and will not be transmitted through sex. In this case, you do not need PrEP. If your partner is newly diagnosed with HIV and has only just started treatment, you may want to consider PrEP until their viral load becomes undetectable. If you have sex without a condom with more than one sexual partner and don’t know their status, HIV PrEP can reduce your chance of becoming infected with HIV.
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