Can we stop our age?

That's because even if you manage to dodge any illnesses, there's ultimately no escaping old age. “Longevity is a side effect of health,” de Grey says. “If we can keep people healthy, then their likelihood of dying is reduced.”

webmd.com - Is There a Cure for Aging? - WebMD.com

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One major hallmark of aging is the growing stockpile of these senescent cells. Damaged cells become deactivated as a way to protect your body from harmful or uncontrolled cell division. But like the rotten apple that spoils the whole bunch, senescent cells encourage their neighbors to turn dysfunctional, too. They also emit proteins that trigger inflammation. Your body naturally removes these dormant cells. But older immune systems have a harder time cleaning up, so the senescent cells are more likely to hang around. Flushing out this accumulated debris may be one way to avert aging, some experts say.

De Grey also believes that could be done with drugs.

“These therapies would actually repair [cellular] damage,” he says. “They’ll eliminate damage from the body by resetting or turning back the clock.” James Kirkland, MD, PhD, of the Mayo Clinic is one researcher exploring this theory. He gave a mixture of the cancer drug dasatinib and a plant pigment called quercetin to people with diabetic kidney disease. Quercetin is an antioxidant that gives grapes, tomatoes, and other fruits and vegetables their flavor. A small phase I clinical trial showed that the dasatinib-quercetin combination got rid of senescent cells in the tissues of people with the disease. The researchers don’t know yet if the results will translate into prolonged youth. They also don’t know how high a dosage is needed and what long-term problems the treatment might cause. People with chronic leukemia take dasatinib for years with few serious ill effects. In another recent study, scientists used oxygen therapy to tackle senescent cells. Thirty-five adults ages 64 and older received oxygen therapy in a pressurized chamber. After 60 daily sessions, they showed a decrease in senescent cells and improvement to the length of DNA segments called telomeres. Shortened segments of telomeres are thought to be another marker of aging. Researchers are also looking to the gene editing technology CRISPR for anti-aging treatments, but the testing is only in mice so far. Barzilai hopes that if the metformin trial succeeds, it will open the floodgates to a wave of new drugs that can stop or reverse human aging. Some of the major players in this field include Juvenescence, AgeX Therapeutics, LyGenesis, and Life Biosciences, which Barzilai founded. “Until aging is seen as preventable, health plans won’t have to pay for this type of treatment,” he says. And if health plans won’t cover aging, pharmaceutical companies have little incentive to invest in drug development. That may be the only thing standing between humans and unprecedented lifespans. The Census Bureau projects that Americans born in 2060 should live an average of 85.6 years, up from 78.7 years in 2018. De Grey’s prediction tops that mark by a factor of about 50. He believes that the life expectancy for someone born in 2100 may well be 5,000 years.

Barzilai, for his part, has a prediction that’s seemingly more modest.

“We die at 80. Getting an additional 35 years is relatively low-hanging fruit,” he says. “But I don’t believe that is a fixed limit.”

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What should I reply after RIP?

A simple "thank you" works. Other short phrases you can say are, "I appreciate it," or "That's very kind." If the other person knew the deceased and is grieving too, you can acknowledge that by also responding, "This must be hard for you, too."

wikihow.com - Simple Ways to Respond to Condolences: 8 Steps (with Pictures)

This article was co-authored by wikiHow Staff . Our trained team of editors and researchers validate articles for accuracy and comprehensiveness. wikiHow's Content Management Team carefully monitors the work from our editorial staff to ensure that each article is backed by trusted research and meets our high quality standards. This article has been viewed 623,140 times.

Article Summary

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While condolences from friends and family after losing a loved one can help you grieve, it’s natural to not know how to respond. When the condolence is in person, a simple and genuine “thank you” or “I appreciate it” is usually enough, since the person won’t be expecting a long conversation. If someone has sent you a heartfelt, handwritten note or card, reply with your own handwritten message once you have taken enough time to grieve. However, don’t feel obligated to respond to generic sympathy cards signed with a name. Since expressing condolences online is more common these days, consider posting a general status on a site like Facebook thanking well-wishers for their support. To learn more, like how to use pre-printed cards from a funeral director, scroll down.

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