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What happens if you take too much PrEP?

If you accidentally take two PrEP pills in one day, it's OK. Taking two PrEP pills is not harmful.

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​ Daily PrEP and periodic PrEP

Both daily PrEP and periodic PrEP are suitable for anal, and vaginal or front hole sex, and injecting drug use. The only difference between daily PrEP and periodic PrEP is the amount of time you choose to use each option — daily PrEP is sometimes considered a longer-term option, while periodic PrEP may only be used for a holiday, party, festival or other short to medium-term duration.

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Using daily or periodic PrEP is as simple as taking one PrEP pill a day, every day. It doesn't matter what time of day you take your PrEP pill and it's OK if it's not exactly the same time every day. Just be sure to take one PrEP pill every 24 hours.

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If you accidentally take two PrEP pills in one day, it's OK. Taking two PrEP pills is not harmful.

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Starting daily or periodic PrEP

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Starting daily or periodic PrEP is different for different people. For cisgender men who have sex with men, start daily or periodic PrEP with a double dose (two pills) at least two hours before sex.

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For everyone else (trans and gender diverse people, cisgender women and men who have sex with women), it takes seven days of daily dosing for PrEP to protect your body. Consider using other forms of HIV prevention for any sex during your first week starting daily or periodic PrEP.

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Missing a dose of daily or periodic PrEP

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Although it's best to use daily or periodic PrEP every day, missing a dose sometimes happens. If you do miss a dose, you don't need to take extra PrEP pills. Simply start your routine again as soon as you remember later that day or the next day.

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For people having anal sex, PrEP still offers extremely high levels of protection even if you miss one dose. However, if you're missing more than one dose and taking less than four pills a week, PrEP may not be able to protect you against HIV.

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For people having vaginal or front hole sex, using PrEP every day is especially important. This is to ensure sufficient levels of drug concentration in vaginal/cervical tissues.

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Stopping daily or periodic PrEP

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If you want to take a break, or discontinue daily or periodic PrEP for any reason, it's recommended to consult your doctor first.

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Stopping daily or periodic PrEP is different for different people. For cisgender men who have sex with men, stop daily or periodic PrEP by continuing to take one PrEP pill every day for two days after your last possible exposure to HIV.

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For everyone else (trans and gender diverse people, cisgender women and men who have sex with women), it's recommended to keep taking one PrEP pill every day for 28 days after your last possible exposure to HIV.

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Before restarting PrEP, check in with your doctor for routine tests, especially if you have had any possible exposures to HIV in the meantime.

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